Pathogenesis of Plaque Psoriasis

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Psoriasis is an inflammatory skin disease that affects ~125 million individuals worldwide. The condition is genetic: there is a 10% chance of developing psoriasis if one parent has this disease. Recent evidence shows that psoriasis may also have an epigenetic component, studies have found dysregulated DNA methylation levels in psoriasis patients (to learn more about epigenetics, read my previous article).